| APIS002 |
vs.4 |
cyclic oligonucleotide-based antiphage signaling system (CBASS) |
CLAN018 |
T4 of E. coli |
PMID:36848932 |
Vs.4 antagonized cGAS signaling by binding tightly to cGAMP (dissociation constant of approximately 30 nM) and sequestering it; Bioinformatic analyses identified 198 homologues of Vs.4 in diverse phages; belongs to PHROG 717. |
| APIS004 |
Acb2 |
cyclic oligonucleotide-based antiphage signaling system (CBASS) |
CLAN018 |
PaMx33 of Pseudomonas aeruginosa |
PMID:36750095 |
Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity. |
| APIS016 |
Acb1 |
cyclic oligonucleotide-based antiphage signaling system (CBASS) |
CLAN019 |
T4 of E. coli |
PMID:35395152 |
Acb1 rapidly degrades the CBASS signals 3′3′-cGAMP, cUA and cAAA, but does not cleave cGG. |
| APIS048 |
|
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CLAN018 |
Ralstonia phage YO108_2 |
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